In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 148017-28-1 as follows. category: amides-buliding-blocks
Step b: (2R3Ry4R,5R)-2-fr(Aminosulfonyl)(f¡ãr^-butoxycarbonyl)amino1methyl}-5-(6- cMoro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate[0462] (2R,3R,4R,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diyl di-acetate (425.0mg, 0.001146mol), N-Boc-sulf amide (337.4mg, 0.001720mol) and triphenylphosphine (360.8mg, 0.001376mol) were dissolved in ethyl acetate (10 mL) under nitrogen and diisopropyl azodicarboxylate (338.6 muL, 0.001720mol) was added dropwise as a solution in ethyl acetate (2mL). The solution was stirred at room temperature under nitrogen for 3h. The solution was concentrated in vacuo and the residue purified by flash chromatography (DCM/ EtOAc 10% to 50%) to give product, contaminated with triphenylphosphine oxide (502mg).[0463] LCMS: R.t. 1.49 min ES+ 549 (formic acid)
According to the analysis of related databases, 148017-28-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/84281; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics