Synthetic Route of 4424-80-0,Some common heterocyclic compound, 4424-80-0, name is 4,5-Dihydro-1H-benzo[b]azepin-2(3H)-one, molecular formula is C10H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 Production of 2,3,4,5-tetrahydro-1H-benzo[b]azepine Lithium aluminum hydride (100 mg) was suspended in tetrahydrofuran (10 mL), 1,3,4,5-tetrahydrobenzo[b]azepin-2-one (245 mg) was added under ice-cooling by small portions. After heating under reflux for 5.5 hrs, water (0.1 mL), 15% aqueous sodium hydroxide (0.1 mL) and water (0.3 mL) were successively added under ice-cooling, and the mixture was stirred at room temperature. The mixture was dried over anhydrous sodium sulfate, and concentrated to give the title compound (301.6 mg) as a yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,5-Dihydro-1H-benzo[b]azepin-2(3H)-one, its application will become more common.
Reference:
Patent; Japan Tobacco Inc.; US2008/64871; (2008); A1;,
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