Related Products of 16982-21-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16982-21-1, name is Ethyl 2-amino-2-thioxoacetate, This compound has unique chemical properties. The synthetic route is as follows.
In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a mixture of amino-thioxo-acetic acid ethyl ester (2.50 g, 18.77 mmol) and 1 ,3-dichloro-propan-2-one (2.88 g, 21.59 mmol) in toluene (20.0 ml.) was stirred for 2 h at reflux. EtOAc (20 ml.) was added at rt and the mixture was washed with sat. aq. NaHCO3 (10 ml.) followed by brine (20 ml_). The organic layer was dried over MgSO4, filtered, and the solvent removed under reduced pressure. Purification of the residue by FC (4:1 hept-EA) gave the title compound as a light yellow oil. TLC: rf (4:1 hept-EA) = 0.26. LC-MS-conditions 02: tR = 0.89 min, [M+H]+ = 206.40.
The chemical industry reduces the impact on the environment during synthesis Ethyl 2-amino-2-thioxoacetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/77990; (2009); A1;,
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