Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103-89-9, name is 4′-Methylacetanilide, A new synthetic method of this compound is introduced below., Recommanded Product: 4′-Methylacetanilide
1a as example: To a stirred suspension of N-(p-tolyl)acetamide 1a (75 mg, 0.5 mmol) and Selectfluor (213 mg, 0.6 mmol) in water (3.0 mL) was added HBr (40% aqueous, 0.08 mL, 0.55 mmol), and the mixture was stirred for 5 min at room temperature. After 1a was consumed, as indicated by TLC, the reaction mixture was quenched with saturated aqueous Na2S2O3 (2.0 mL) and water (20.0 mL), and extracted with CH2Cl2 (10.0 mL) three times. The residue obtained after evaporation of the solvent was purified by column chromatography on silica gel (petroleum ether-ethyl acetate = 6:1, v/v) to afford N-(2-bromo-4-methylphenyl)acetamide 2a as a white solid (108 mg, 95% yield).
The synthetic route of 103-89-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liang, Deqiang; Li, Xiangguang; Wang, Chaowu; Dong, Qishan; Wang, Baoling; Wang, Hai; Tetrahedron Letters; vol. 57; 48; (2016); p. 5390 – 5394;,
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