In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22503-72-6 as follows. Product Details of 22503-72-6
To an ice-cooled solution of 1 (233 mg, 1.0 mmol) in CH2Cl2 (10mL) was added dropwise an excess of MCPBA (1478 mg, 6.0mmol, 70%) in CH2Cl2 (10 mL) previously cooled in an ice bath.The mixture was allowed to gradually warm to r.t., with stirring,over 12 h. TLC and LC-MS analyses were used to monitor reactionprogress. When the reaction was complete, the solution was stirredwith excess powered anhydrous Na2CO3 until carbon dioxide evolutionceased. After filtration, the mixture was concentrated in vacuoat r.t. to give pure 2.Yield: 275 mg (99%); yellow solid; mp 160-163 C.IR (KBr): 3160, 3101, 2990, 1600, 1550, 1350, 850 cm-1.1H NMR (400.13 MHz, CDCl3): delta = 2.48 (s, 3 H, CH3), 7.63 (d,J = 9.0 Hz, 1 H, ArH), 7.98 (d, J = 9.0 Hz, 1 H, ArH), 8.06 (s, 1 H,ArH), 9.25 (br s, 1 H, NH).13C NMR (100.62 MHz, CDCl3): delta = 16.8, 125.4, 126.9, 133.0,135.8, 138.1, 143.5, 165.7.HRMS (ESI): m/z [M + H]+ calcd for C8H7ClN2O5S: 278.9842;found: 278.9840.
According to the analysis of related databases, 22503-72-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Cannazza, Giuseppe; Perrone, Serena; Rosato, Francesca; D’Accolti, Lucia; Parenti, Carlo; Troisi, Luigino; Synthesis; vol. 46; 7; (2014); p. 962 – 966;,
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