Some common heterocyclic compound, 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate, molecular formula is C11H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C11H16N2O2
General procedure: Mucohalic acid (1 eq) was added to a solution of 5:3 v/v dichloromethane/glacial acetic acid. Then, an amine (1 eq) was added, and the mixture was stirred for 10 min. To that mixture, sodium triacetoxyborohydride (3 eq) solution in 5:3 v/v dichloromethane and glacial acetic acid was added. The mixture was left to stir at room temperature for 24 h unless otherwise stated.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 71026-66-9, its application will become more common.
Reference:
Article; Almohaywi, Basmah; Taunk, Aditi; Wenholz, Daniel S.; Nizalapur, Shashidhar; Biswas, Nripendra N.; Ho, Kitty K. K.; Rice, Scott A.; Iskander, George; Black, David StC.; Griffith, Renate; Kumar, Naresh; Molecules; vol. 23; 5; (2018);,
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