57561-39-4, name is tert-Butyl (2-hydroxyethyl)(methyl)carbamate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of tert-Butyl (2-hydroxyethyl)(methyl)carbamate
Compound 20 (10 g, 57 mmol)Soluble in 250mL of dry dichloromethane,Nitrogen bubbling,Dess-Martin oxidant (DMP, 26.6 g) was added in portions at 0 C.Add the room temperature reaction,TLC (PE/EA = 1/1) monitors the progress of the reaction.Post-processing,Add 500 mL of saturated sodium bicarbonate solution,500mL saturated aqueous sodium thiosulfate solution andStir in 800 mL of dichloromethane for 30 min.Layered, the organic layer is saturated with sodium bicarbonate,Saturated with sodium chloride,Dry over anhydrous sodium sulfate, filter,Concentration under reduced pressure gave a white oil, 8.65 g.
The synthetic route of 57561-39-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan Bai Li Pharmaceutical Co., Ltd.; Zhu Yi; Li Jie; Wan Weili; Zhuo Shi; Li Gangrui; (28 pag.)CN109106951; (2019); A;,
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