Electric Literature of 40545-33-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40545-33-3 as follows.
General procedure: Sodium hydrogen sulfite (4 mmol) was added to a solution of anthranilamide 1 (2 mmol) and benzaldehyde 2 (2 mmol) in N,N- dimethylacetamide (5 mL). The mixture was heated under continuous stirring at 150 o C for 2-3 h and poured into ice water. The precipitate was then filtered, washed with water followed byethanol, and dried to yield the 2-arylquinazolinones 3-31. 5.1.2. 6-Methyl-2-(naphthalen-1-yl)quinazolin-4(3H)-one (3)Yield 434 mg (76%). Light-yellow solid. Mp: 264e265 C. IR(cm1): 3421 (NH), 3041, 1677 (C]O). 1H NMR (500 MHz, DMSOd6)d (ppm): 12.5 (s, 1H); 8.15 (d, J 7.5 Hz, 1H), 8.10 (d, J 8.5 Hz,1H), 8.05e8.02 (m, 2H); 7.78 (d, J 7.5 Hz, 1H), 7.69e7.56 (m, 5H),2.50 (s, 3H). 13C NMR (125 MHz, DMSO-d6) d (ppm): 161.7, 152.7, 146.6, 136.4, 135.7, 133.0, 131.7, 130.2, 128.2, 127.5, 127.2, 126.9,126.2, 125.16, 125.13, 125.0, 120.9, 20.8. HRMS (ESI): m/z 287.1181 (M H) (calcd for C19H15N2O, 287.1184).
According to the analysis of related databases, 40545-33-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Khadka, Daulat Bikram; Tran, Giap Huu; Shin, Somin; Nguyen, Hang Thi Minh; Cao, Hue Thi; Zhao, Chao; Jin, Yifeng; Van, Hue Thi My; Chau, Minh Van; Kwon, Youngjoo; Le, Thanh Nguyen; Cho, Won-Jea; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 69 – 79;,
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