Related Products of 94838-59-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 94838-59-2 name is tert-Butyl 4-aminophenethylcarbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of formaldehyde (0.303 g, 4 mmol, 40% in water), fert-butyl 4- aminophenethylcarbamate (1.135 g, 4.8 mmol) and NaBH3CN (1.257 g, 20 mmol) in methanol (14 mL) was stirred at room temperature for 4 h. Water (30 mL) was added to the reaction mixture afterward and the mixture was extracted with ethyl acetate (30 mL 3). The organic layer was washed with water (20 mL) and brine (20 mL), dried with NaiSCri and concentrated. The residue was purified by column chromatography to afford the title compound as colorless oil (0.337 g, 33.7 % yield). NMR (500 MHz, DMSO-riri) d: (d, J= 8.3 Hz, 2H), 6.79 (t, J= 5.3 Hz, 1H), 6.46 (d, J= 8.4 Hz, 2H), 5.41 (q, J= 5.0 Hz, 1H), 3.03 (dd, J= 14.9, 6.1 Hz, 2H), 2.64 (d, J= 5.2 Hz, 3H), 2.54 – 2.51 (m, 2H), 1.38 (s, 9H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 4-aminophenethylcarbamate, and friends who are interested can also refer to it.
Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
Amide – Wikipedia,
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