These common heterocyclic compound, 5338-44-3, name is Ethyl 4-acetamidobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H13NO3
General procedure: To a solution of amidoxime 1 (2 mmol) and ester 2 (3 mmol) inDMSO (2 mL) 120 mg (3 mmol) powdered NaOH was rapidlyadded.The reaction mixture was stirred at room temperature for therequired time (TLC or precipitation of the product). The reactionmixture was diluted with cold water (30e50 mL). The resultingprecipitate was ltered off, washed with water (30 mL) and dried inair at 50 C.
The synthetic route of Ethyl 4-acetamidobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Baykov, Sergey; Sharonova, Tatyana; Shetnev, Anton; Rozhkov, Sergey; Kalinin, Stanislav; Smirnov, Alexey V.; Tetrahedron; vol. 73; 7; (2017); p. 945 – 951;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics