Electric Literature of 132289-57-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 132289-57-7, name is N,2-Dimethoxy-N-methylacetamide, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of the above amide (260mg) in THF (5ml) at-78 C was added a solution of 2-thienyllithium (1 M in THF, 2. 15ml). The solution was stirred for 2hr at-78 C and warmed to-20 C for an additional 2hr. The reaction was quenched with saturated ammonium chloride and extracted with CH2CI2, washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo to give 250mg of product (82%).
The chemical industry reduces the impact on the environment during synthesis N,2-Dimethoxy-N-methylacetamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Amide – Wikipedia,
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