Synthetic Route of 125414-41-7, The chemical industry reduces the impact on the environment during synthesis 125414-41-7, name is tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate, I believe this compound will play a more active role in future production and life.
2.97 g of lipoic acid (LA), 3.31 g of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC¡¤HCl) was added to a 100 mL round bottom flask.Add 40 mL CH2Cl2 to dissolve and activate for 30 min.1.25 g of Boc-serinol dissolved in 20 mL of CH 2 Cl 2 and 2.21 g of 4-(dimethylamino)pyridine (DMAP) were added to the above mixture.Reaction for 12 h. After the reaction is completed, it is filtered.The filtrate was thoroughly washed with an excess of 0.1 mol/L hydrochloric acid.Discard the water phase after standing. Dry the oil phase with sodium sulfate and purify by column chromatography (eluent: CHCl3/CH3OH=20/1, v/v) to give a pale yellowOily liquid di-Boc-LA-Ser (3.19 g, yield 86%).Take 1g di-Boc-LA-Ser in 10mL CH2Cl2,After cooling to 0 C, 0.41 g of trifluoroacetic acid (TFA) was slowly added dropwise and reacted for 2 h.The mixture was concentrated in vacuo to give a crude di-L-Ser.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Southeast University; Li Xinsong; Ling Longbing; He Wei; (21 pag.)CN109224082; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics