Electric Literature of 40724-47-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 40724-47-8 name is 4-Bromomethylbenzenesulfonamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate 9a (0.2 g, 0.51 mmol) was dissolvedN, N-dimethylformamide (10 mL)P-Bromomethylbenzenesulfonamide was added(0.19 g, 0.76 mmol)And potassium carbonate(0.11 g, 0.76 mmol)After stirring overnight at room temperature, the reaction solution was filtered,Vacuum concentration under the pump,The ethyl acetate was dissolved (50 mL) and washed with water (20 mL x 3)Saturated salt washing, anhydrous sodium sulfate drying,After filtration and concentration,Silica gel column chromatography,The product was washed with methanol to give the product (0.24 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromomethylbenzenesulfonamide, and friends who are interested can also refer to it.
Reference:
Patent; Shandong University; Liu, Xinyong; Zhang, Heng; Zhan, Peng; Zhou, Zhongxia; Kang, Dongwei; (26 pag.)CN106117242; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics