The synthetic route of 4815-28-5 has been constantly updated, and we look forward to future research findings.
Synthetic Route of 4815-28-5,Some common heterocyclic compound, 4815-28-5, name is 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, molecular formula is C9H12N2OS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 492-(2-(3-(trifluoromethyl)-4,5,6,7-tetrahydroindazole-1-yl)propanamido)-4,5,6,7- tetrahydrobenzorithiophene-3-carboxamide a) 2-(3-chloropropanamido)-4,5,6,7-tetrahydrobenzo[]thiophene-3-carboxamide2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (250 mg, 1.28 mmol) and triethylamine (0.18 ml_, 1.28 mmol) were stirred in DCM (5 ml_). 3-chloropropionylchloride (162 mg, 1.28 mmol) was added dropwise under a nitrogen atmosphere. Stirring was continued for 2 h. 2 M HCI (20 ml_) was added and the reaction mixture extracted into DCM (3 x 50 ml_), The combined DCM layers were washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to give the desired product as a yellow solid (290 mg, 1.01 mmol, 79 %).1 H NMR (400MHz, CDCI3): delta 1.86 (m, 4H), 2.72 (m,4H), 2.91 (t,2H), 3.86 (t, 2H), 5.73 (s, 2H), 12.1 (s,1 H).
The synthetic route of 4815-28-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; N.V. ORGANON; WO2008/3452; (2008); A1;,
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