Application of 7150-72-3, A common heterocyclic compound, 7150-72-3, name is tert-Butyl vinylcarbamate, molecular formula is C7H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A suspension of tert-butyl N-vinylcarbamate (25.0 g) and Potassium carbonate (49.2 g) in Tetrahydrofuran (262 mL) was cooled to 0-5C. To this mixture was then added a solution of dibromomethanone oxime (39.0 g) in tetrahydrofuran (89.0 mL) at 0-5C and was stirred for one hour. The reaction mixture was then stirred at rt for 3 hours. The mixture was then extracted twice between ethyl acetate and water. The combined organic layers were dried (MgSO4), filtered and evaporated under vacuo to give a 46.1 g of a crude compound.30 g of this crude were stirred with 50 ml of diethylether for 2 hours. The resulting beige suspensionwas filtered, washed with 2x 20 ml of diethylether and 2x 50m1 of pentane then was dried under vacuo to give 26.54 g of a white solid corresponding to the desired tert-butyl N-(3-bromo-4,5-dihydroisoxazol- 5-yl)carbamate. 1H-NMR(CDCI3, 400 MHz, oe in ppm): 1.47 (s, 9 H)2.95(dd, J=18, 4.8 Hz, 1 H)3.49 (dd, J=18, 9.7 Hz, 1 H) 5.42 (br. s., 1 H) 6.15 (br. s., 1 H)
The synthetic route of 7150-72-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; O’SULLIVAN, Anthony, Cornelius; EL QACEMI, Myriem; CASSAYRE, Jerome, Yves; PITTERNA, Thomas; STOLLER, Andre; (137 pag.)WO2017/50921; (2017); A1;,
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