Application of 79722-21-7, A common heterocyclic compound, 79722-21-7, name is tert-Butyl benzyloxycarbamate, molecular formula is C12H17NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of N-Boc-benzyloxyamine (2 ¡¤ lg, 9.44 mmol, 1.2 eq) in DMAC (20 ml) was added potassium tert-butoxide (1.06 g, 9.44 mmo 1,1 ¡¤ 2 eq) After 30 min, a solution of compound 8 (4 ¡¤ Og, 7 ¡¤ 87 mmo 1) in DMAC (20 ml) was added and the reaction was quenched at room temperature for 10 h. The reaction was quenched with saturated ammonium chloride solution (30 ml), concentrated, And the aqueous phase was extracted with ethyl acetate (50 ml * 2), washed with saturated brine (20 ml), dried over anhydrous sodium sulfate and concentrated to give compound 9 (3.788, 95%). The 111 bandits 1? (4001 hold, 0) (: 13): 38.01
The synthetic route of 79722-21-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Kaimo Biological Technology Co., Ltd.; Tian Yanli; Li Yang; (14 pag.)CN105061425; (2017); B;,
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