Related Products of 3984-14-3, The chemical industry reduces the impact on the environment during synthesis 3984-14-3, name is N,N-Dimethylsulfamide, I believe this compound will play a more active role in future production and life.
(+/-)-13-Cyclohexyl-N-[(dimethylamino)sulfonyl]- 6, 7-dihydro-6-hydroxy -5H- indolo[2, 1-a] [2]benzazepne-l 0-carboxamide.l-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (11.5mg, 0.06 mmol) was added to a solution of (+/-)13-cyclohexyl-6,7-dihydro-6-hydroxy – 5H-indolo[25l-a][2]benzazepine-10-carboxylic acid (7.5 mg, 0.02 mmol) and DMAP(7.4 mg, 0.06 mmol) in DMF (0.5 mL) and CH2Cl2 (0.5 mL) at 22 C. The vial was shaken for a minute at 22 0C. N5N-Dimethylsulfamide (4.9 mg, 0.04 mmol) was then added. Stirring was continued for 18 hr. The solution was filtered and purified on the Shimadzu preparative liquid chromatograph. The product containing fraction was concentrated on a Speed Vac to leave the titled compound as a white film (3.0 mg, 30 %). ESI-MS m/z 482 (MH+); IH NMR (500 MHz, MeOD) delta 1.26-
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethylsulfamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/92000; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics