Electric Literature of 71026-66-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71026-66-9 name is tert-Butyl (4-aminophenyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of 2-chloroethanesulfonyl chloride (1.56 g, 9.57 mmol) in THF (10 mL) was added dropwise N-methylaniline (989 mg, 9.23 mmol) followed by triethylamine (5 mL, 36 mmol) at 0 C. After stirring for 3 h, ethyl acetate was added, and the reaction mixture was washed with 3 M hydrochloric acid then brine, dried over magnesium sulfate, evaporated in vacuo to obtain 1.76 g (97%) of vinylsulfonamide 3a as a pale brown solid. The product was spectroscopically pure, and was used without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (4-aminophenyl)carbamate, and friends who are interested can also refer to it.
Reference:
Article; Kihara, Nobuhiro; Mitsuhashi, Yuji; Sato, Makoto; Hirose, Shun-Ichi; Goudo, Erika; Uzawa, Yoshinori; Shirai, Natsumi; Hamamoto, Sari; Iwasaki, Ryo; Fujioka, Akane; Tetrahedron Letters; vol. 57; 23; (2016); p. 2563 – 2566;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics