The important role of 316146-27-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 316146-27-7, name is N-(4-Bromophenyl)-3-phenylpropanamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 316146-27-7, HPLC of Formula: C15H14BrNO

b. Preparation of intermediate 10; The reaction was carried out twice . POCl3 (1.225 mol) was added dropwise at 10¡ãC to DMF (0.525 mol) . Then intermediate 9 (0.175 mol) was added at room temperature . The mixture was stirred overnight at 80¡ãC, poured out on ice and extracted with CH2Cl2 . The organic layer was dried (MgSO4), filtered, and the solvent was evaporated . Yield: 77.62 g of intermediate 10 (67 percent).

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Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/436; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The origin of a common compound about 89976-75-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Amino-2H-1,4-benzoxazin-3(4H)-one, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 89976-75-0, name is 6-Amino-2H-1,4-benzoxazin-3(4H)-one, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89976-75-0, Quality Control of 6-Amino-2H-1,4-benzoxazin-3(4H)-one

Ci 6-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propylamino]- 4H-benzo[l, 4] oxazin-3-one:To a solution of ter.pound.-butyl-dimethyl-((5)-l-oxiranylmethoxy)-silane (commercial; 10.0 g, 53 mmol) in MeCN (16O mL) was added LiClO4 (16.9 g, 159 mmol). 6-amino- 4H-benzo[l,4]oxazin-3-one (commercial; 8.72 g, 53.1 mmol) was added and the mixture was stirred at 500C for 6 h. The solvent was removed in vacuo and the residue was purified by CC (DCM/MeOeta/Neta4Oeta 1000:25:2 -> 1000: 100:2) to afford the title compound as a pale brown foam (10.24 g, 55percent yield). MS (ESI, m/z): 353.3 [M+H+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Amino-2H-1,4-benzoxazin-3(4H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/104159; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Research on new synthetic routes about 21440-97-1

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Adding a certain compound to certain chemical reactions, such as: 21440-97-1, name is 6-Bromo-4,4-dimethyl-1,4-dihydrobenzo[d][1,3]oxazin-2-one, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21440-97-1, SDS of cas: 21440-97-1

A solution of 61(500 mg, 1.95 mmol), benzyl mercaptan (0.34 mL, 2.92 mmol), i-Pr2NEt (1.03 mL, 5.90mmol), Pd2(dba)3 (90 mg, 0.098 mmol) and XantPhos (113mg, 0.195 mmol) in dioxane (10 mL) was degassed with N2 for 5 min.The mixture was then heated to 100 C for 5 h. The crude reaction mixture was dry-loaded onto silica gel and purified via ISCO flash column chromatography(eluting with 40% EtOAc in hexanes) to afford 62 (550 mg, 94%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Lotesta, Stephen D.; Marcus, Andrew P.; Zheng, Yajun; Leftheris, Katerina; Noto, Paul B.; Meng, Shi; Kandpal, Geeta; Chen, Guozhou; Zhou, Jing; McKeever, Brian; Bukhtiyarov, Yuri; Zhao, Yi; Lala, Deepak S.; Singh, Suresh B.; McGeehan, Gerard M.; Bioorganic and Medicinal Chemistry; vol. 24; 6; (2016); p. 1384 – 1391;,
Amide – Wikipedia,
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Some tips on 120157-97-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-2-(4-Bromophenyl)ethylamine, other downstream synthetic routes, hurry up and to see.

Application of 120157-97-3, The chemical industry reduces the impact on the environment during synthesis 120157-97-3, name is N-Boc-2-(4-Bromophenyl)ethylamine, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of N-boc-2-(4-bromophenyl)ethylamine, the desiredarylboronic acid (a-m) (1.2 equiv), tetrakis(triphenylphosphine)-palladium(0) (0.04 equiv), Na2CO3 (5 equiv) in degassed toluene/H2O (5/2) was refluxed for 18 h. The reaction mixture was filteredthrough Celite and concentrated in vacuo. The resulting residuewas dissolved in in EtOAc (200 mL), washed with H2O (200 mL 2) and brine (200 mL). The organic layer was dried with anhydrousNa2SO4 and concentrated in vacuo. The residue was purified by columnchromatography on SiO2. Using Method E, 13 (0.50?g, 1.7?mmol), 4-(trifluoromethyl)phenylboronic acid (0.38?g, 2.0?mmol), tetrakis(triphenylphosphine)palladium(0) (0.08?g, 0.1?mmol), Na2CO3 (0.89?g, 8.3?mmol) in toluene/H2O (16?ml/6.6?ml), followed by 4.0?M HCl in dioxane (1.25?ml, 5.0?mmol) gave 14b as a white solid (0.28?g, 56%): Rf?=?0.00 (EtOAc 9: acetone 1): 1H NMR (DMSO-d6, 400?MHz) delta 3.01-3.11 (m, NH3CH2CH2), 7.44 (d, J?=?8.1?Hz, 2 ArH), 7.71-7.91 (m, 6 ArH), 8.37 (s, NH3); 13C NMR (DMSO-d6, 75?MHz) delta 33.0 (NCH2CH2), 124.8 (CF3, q, JC-F?=?270.1?Hz), 126.2 (q, JC-F?=?3.8?Hz), 127.6, 127.7, 128.2 (q, JC-F?=?31.7?Hz), 129.9, 137.4, 138.4, 144.3 (12 ArC).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-2-(4-Bromophenyl)ethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yeon, Seul Ki; Choi, Ji Won; Park, Jong-Hyun; Lee, Ye Rim; Kim, Hyeon Jeong; Shin, Su Jeong; Jang, Bo Ko; Kim, Siwon; Bahn, Yong-Sun; Han, Gyoonhee; Lee, Yong Sup; Pae, Ae Nim; Park, Ki Duk; Bioorganic and Medicinal Chemistry; vol. 26; 1; (2018); p. 232 – 244;,
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Brief introduction of 147291-66-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-aminobenzylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference of 147291-66-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 147291-66-5, name is tert-Butyl 3-aminobenzylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of3 g (13.5 mmol) (3-amino-benzyl)-carbamic acid tert-butyl ester (WO 9740028 Al) and 1.81 ml (13.5 mmol) benzoyl isothiocyanate in 60 ml THF was stirred at room temperature for 1 h and afterwards evaporated under reduced pressure. 80 ml MeOH and 5.6 g (40.5 mmol) potassium carbonate in 80 ml water were added and the mixture was stirred at room temperature for 16 h. The mixture was concentrated under reduced pressure and extracted with ethyl acetate. The organic layers were washed with saturated NaHCO3 solution and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica eluding with a gradient of hexane/ethyl acetate to yield after evaporation of the product fractions 3.56 g (94%) of the title compound as yellow amorphous solid. 1-H-NMR (300 MHz, DMSO d6) ?=1.39 (s, 9H, Boc), 4.10 (d, J=6.0 Hz, 2H, CH2), 6.9-7.4 (m, 7H, Ar+NHBoc+NH2), 9.69 ppm (s, 1H, NH). MS (m/e): 282.0 (MH+, 100%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-aminobenzylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Neidhart, Werner; Nettekoven, Matthias Heinrich; Pflieger, Philippe; US2005/38089; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Extracurricular laboratory: Synthetic route of 40724-47-8

The synthetic route of 40724-47-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40724-47-8, name is 4-Bromomethylbenzenesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4-Bromomethylbenzenesulfonamide

[0174] In a microwave tube was placed ethyl 2-(3 -([1,1? -biphenyll -3-yl)-4-(4,4 ,5 ,5- tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- 1 H-pyrazol- 1 -yl)thiazole-4-carboxylate (91 mg, 0.1 mmol), 4-(bromomethyl)benzenesulfonamide (25.01 mg, 0.100 mmol), and Pd(Ph3P)4 (11.56 mg, 10.00 tmol). The tube was sealed and air was removed and re-filled with N2 (2-3 times). A mixture of toluene (0.75 ml, ratio: 2.500)/EtOH (0.3 ml, ratio: 1.000) was added, and then 2N Na2CO3(aq) (0.3 mL, 0.6 mmol, 6 equiv) was added. The mixture was stirred at 80 ¡ãC (pre-heated) for 2 h. The organic layer was separated, and the aqueous layer was extracted with EtOAc (2 mL x 3). The combined organic layer was dried (Na2504) and filtered. After removal of the solvent, the product was purified by silica gel chromatography using 30-60percent EtOAc/hexane as the eluent to give ethyl 2-(3-([1,1?-biphenyll-3-yl)-4-(4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4-carboxylate 20 (35 mg, 0.064 mmol, 64.3percent yield) as a white solid. Some of the reduction product (ca. 30 mg) from either the reaction and/or from a previous step was collected and subjected to hydrolysis to give 22 (see Example 31, Scheme7A).

The synthetic route of 40724-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; MALONEY, David J.; JADHAV, Ajit; BANTUKALLU, Ganesha Rai; BRIMACOMBE, Kyle Ryan; MOTT, Bryan T.; YANG, Shyh Ming; URBAN, Daniel Jason; HU, Xin; SIMEONOV, Anton; KOUZNETSOVA, Jennifer L.; WATERSON, Alex Gregory; SULIKOWSKI, Gary Allen; KIM, Kwangho; CHRISTOV, Plamen; JANA, Somnath; (387 pag.)WO2016/109559; (2016); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Analyzing the synthesis route of 79-16-3

The synthetic route of 79-16-3 has been constantly updated, and we look forward to future research findings.

Reference of 79-16-3, A common heterocyclic compound, 79-16-3, name is N-methylacetamide, molecular formula is C3H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A Schlenk tube was charged with amide (1.2 mmol), aryl iodides (1 mmol), CuI (0.1 mmol), N,N-dimethylglycine (0.2 mmol), and potassium phosphate (2 mmol). The tube was evacuated and backfilled with argon at room temperature. DMF (0.5 mL) was added under argon via syringe. The Schlenk tube was immersed in a preheated oil bath and the reaction mixture was stirred for the specified time at the indicated temperature. The cooled mixture was partitioned between water and ethyl acetate. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (eluting with 1:8 to 1:2 ethylacetate/petroleum ether) to give the the desired N-aryl amides.

The synthetic route of 79-16-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jiang, Liqin; Molecules; vol. 19; 9; (2014); p. 13448 – 13460;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some tips on 21744-84-3

The synthetic route of 4-Methyl-2H-1,4-Benzoxazin-3-one has been constantly updated, and we look forward to future research findings.

Reference of 21744-84-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21744-84-3, name is 4-Methyl-2H-1,4-Benzoxazin-3-one belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of (2-chloro-5-methoxy-phenyl)-acetic acid (1 g) in tetrahydrofuran (20 ml) were added N,N-dimethylformamide (2 drops) and oxalylchloride (1.03 g). The mixture was stirred overnight at room temperature. The solvent was evaporated; toluene was added and again evaporated. The residue was dried under high vacuum to give the crude acid chloride. To a cooled solution (ice bath) of 4-methyl-2H-1,4-benzoxazin-3(4H)-one (830 mg) in 1,2-dichloroethane (5 ml) was added AlCl3 (1.99 g). The mixture was stirred for 10 min and a solution of the acid chloride in 1,2-dichloroethane (5 ml) was added dropwise. The mixture was stirred at 0 C. for 4.5 h. The mixture was poured into ice water and hydrochloric acid and extracted with dichloromethane. The organic phase was dried (MgSO4), filtered and concentrated. The product was purified by chromatography (SiO2, cyclohexane/EtOAc 1_0=>0:1) to give the title compound (1.6 g) as an off-white solid. MS (m/e)=346.1 [M+H-].

The synthetic route of 4-Methyl-2H-1,4-Benzoxazin-3-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

New downstream synthetic route of 402-46-0

The synthetic route of 402-46-0 has been constantly updated, and we look forward to future research findings.

402-46-0, name is 4-Fluorobenzenesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H6FNO2S

To a solution of 4-fluorobenzenesulfonamide (1 .02 g, 5.71 mmol) in H20 (10 mL) was added piperazine (2.46 g, 28.55 mmol). The reaction mixture was stirred at 100 00 overnight. The mixture was cooled to room temperature and filtered. The filtration cake was washed with H20 (20 mL), toluene(30 mL) and ether (30 mL) to give 26.1 (401 mg, 29% yield). MS (ESI) m/z = 242.0 [M¡ÂH]. 1H NMR (400 M, DMSO-c), oe 7.60 (d, J = 8.8 Hz, 2H), 7.05 (m, 2H), 7.00 (d, J = 8.8 Hz, 2H), 3.17 (m, 4H), 2.80 (m, 4H), 2.33 (m, 1H).

The synthetic route of 402-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Research on new synthetic routes about 194920-62-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate, and friends who are interested can also refer to it.

Synthetic Route of 194920-62-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 194920-62-2 name is tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 7 (10.8 g, 30.3 mrnol, 1.0 equiv) in DCM (400 mL) was treated at 4 C with triethylamine (5.29 mL, 37.9 minol, 1.3 equiv), followed by allyl chloroformate (3.56 mL, 33.4 rnmol, 1.1 equiv) . After 15 mm, the reaction was allowed to warm to room temperature and was stirred for 2 h. Then, the reaction mixturewas washed with water (3 x 250 mL), dried over MgSO4, filtered and concentrated under reduced pressure. The product waspurified by flash chromatography (200 g SiC2 ethylacetate/hexanes 1:1, then ethyl acetate) to give 8 (11.0 g, 90%)as a colorless oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; ETH ZURICH; CARREIRA, Erick, Moran; SCHAFROTH, Michael, Andreas; SOBOTZKI, Nadine; WOLLSCHEID, Bernd; (67 pag.)WO2017/81069; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics