Adding a certain compound to certain chemical reactions, such as: 24243-71-8, name is Propane-1-sulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24243-71-8, Quality Control of Propane-1-sulfonamide
Example 119 1-(2-Chlorobenzyl)-2-Methyl-6-(2-Propanesulfonylcarbamoyl) Benzimidazole By using the method of example 111, 1-(2-chlorobenzyl)-2-methyl-6-(2-propanesulfonylcarbamoyl)benzimidazole (0.417 g) is obtained from 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole (0.400 g) (example 75), N,N’-carbonyldiimidazole (0.431 g), 1-propanesulfonamide (0.328 g) and diazabicycloundecene (0.404 g). 1H-NMR (DMSO-d6, delta): 1.30 (6H, d, J=6.9 Hz), 2.50 (3H, s), 3.81-3.87 (1H, m), 5.62 (2H, s), 6.46 (1H, d, J=7.7 Hz), 7.25 (1H, t, J=7.5Hz), 7.35 (1H, t, J=7.5 Hz), 7.62 (1H, d, J=7.9 Hz), 7.69 (1H, d, J=8.5 Hz), 7.81 (1H, d, J=8.6 Hz), 8.12 (1H, s), 11.8 (1H, s). IR(KBr): 1670 cm-1. mp: 215.0-217.5 C. (R1=2-chlorobenzyl, R7=methyl, R3=-C(O)NR4R5, R4=SO2R6, R5=H, R6=propyl, n=1, y=0)
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Reference:
Patent; Cell Pathways, Inc.; US6348032; (2002); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics