Adding a certain compound to certain chemical reactions, such as: 1314538-55-0, name is Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1314538-55-0, Product Details of 1314538-55-0
84- iii (0.27 g, 0.45 mmol, 1 .0 equiv), potassium (((tert-butoxycarbonyl) amino) methyl) trifluoroborate (0.21 g, 0.89 mmol, 2.0 equiv) were added to toluene: water (5: 0.5) and the reaction mixture was degassed for 5 minutes. Pd (ll)OAc (0.005 g, 0.022 mmol, 0.05 equiv), RuPhos (0.02 g, 0.044 mmol, 0.1 equiv), K2CO3 (0.19 g, 1 .34 mmol, 3.0 equiv) were added and the reaction mixture was stirred at 80 C for 24 hours. The reaction mixture was quenched with cold water and extracted with EtOAc. The organic layer was washed with brine, dried over sodium sulfate and concentrated to afford a crude residue. The crude residue was purified by preparative HPLC purification to afford the desired product 85-i (0.038 g, 15 % yield). 1H NMR (400 MHz, MeOD) delta 7.27 (s, 1 H), 7.09 (s, 1 H), 6.43 (s, 1 H), 4.49 (s, 2H), 3.96 – 3.80 (m, 2H), 3.53 (dd, J = 18.0, 5.8 Hz, 5H), 2.47 (s, 3H), 2.23 (d, J = 7.5 Hz, 1 H), 2.18 (d, J = 7.7 Hz, 1 H), 1 .48 (d, J = 10.2 Hz, 18H), 1 .15 (d, J = 5.5 Hz, 1 H), 0.90 (d, J = 7.1 Hz, 1 H), 0.53 – 0.43 (m, 2H) LCMS (m/z): 581 .5 [M+H]
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; FIDALGO, Javier De Vicente; HE, Haiying; HU, Cheng; JIANG, Zhigan; LI, Xiaolin; LU, Peichao; MERGO, Wosenu; MUTNICK, Daniel; RECK, Folkert; RIVKIN, Alexey; SKEPPER, Colin Kevin; WANG, Xiaojing Michael; XIA, Jianhua; XU, Yongjin; (285 pag.)WO2016/20836; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics