Adding a certain compound to certain chemical reactions, such as: 89976-75-0, name is 6-Amino-2H-1,4-benzoxazin-3(4H)-one, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89976-75-0, Quality Control of 6-Amino-2H-1,4-benzoxazin-3(4H)-one
Ci 6-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propylamino]- 4H-benzo[l, 4] oxazin-3-one:To a solution of ter.pound.-butyl-dimethyl-((5)-l-oxiranylmethoxy)-silane (commercial; 10.0 g, 53 mmol) in MeCN (16O mL) was added LiClO4 (16.9 g, 159 mmol). 6-amino- 4H-benzo[l,4]oxazin-3-one (commercial; 8.72 g, 53.1 mmol) was added and the mixture was stirred at 500C for 6 h. The solvent was removed in vacuo and the residue was purified by CC (DCM/MeOeta/Neta4Oeta 1000:25:2 -> 1000: 100:2) to afford the title compound as a pale brown foam (10.24 g, 55percent yield). MS (ESI, m/z): 353.3 [M+H+].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Amino-2H-1,4-benzoxazin-3(4H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/104159; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics