Synthetic Route of 5511-18-2, The chemical industry reduces the impact on the environment during synthesis 5511-18-2, name is Adamantane-1-carboxamide, I believe this compound will play a more active role in future production and life.
A solution of adamantanecarboxamide (1 mmol) in THF (4 mL) was treated with LiAIH4 (4 mmol) at 0 C and stirred under a N2 atmosphere whilst warming to room temperature. After 2 h, the reaction was heated at reflux for 16 h and then cooled on ice. Chilled H20 (150 pL) was added dropwise, with vigorous stirring, and then followed by aqueous sodium hydroxide (15% wiv, 150 pL) and additional water (0.5 mL). The solution was left stirring at room temperature until effervescence had ceased and the grey powder had turned white (30 min). The solution was dried (MgS04) and then filtered. The precipitate was washed with additional dichloromethane (2 x 4 mL). The filtrates in each case were combined. Purification was carried out as follows
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Adamantane-1-carboxamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE UNIVERSITY OF SYDNEY; KASSIOU, Michael; FIGTREE, Gemma; O’BRIEN-BROWN, James; WILKINSON, Shane; HANSEN, Thomas; (64 pag.)WO2020/37350; (2020); A1;,
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