These common heterocyclic compound, 193751-54-1, name is tert-Butyl cyclopent-3-en-1-ylcarbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H17NO2
Solid NAHCO3 (0.0167 mol) and M-CPBA (0. 0128 mol) were added in portions to a stirred solution of cyclopent-3-enyl-carbamic acid tert-butyl ester IV-1 (0.0093 mol) in CH2C12 (60 mL). The mixture was stirred at 0 C for the first 2 h of the reaction and then allowed to stir for about 48 h at room temperature. Aqueous 20% NA2S03 (30 mL) was added, and the two layers were separated. The aqueous layer was extracted with CH2C12 (20 mL X 3), and the combined organic layers were washed with 20% NA2SO3 (30 mL X 1), 5 % NAHCO3 (30 mL X 1), and water (30 mL X 1). The combined organic phase was concentrated in vacuo, and the residue was purified by column chromatography (silica gel, 100% dichloromethane) to give pure product as a colorless oil (64%).
The synthetic route of tert-Butyl cyclopent-3-en-1-ylcarbamate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NORTHWESTERN UNIVERSITY; WO2005/26111; (2005); A2;,
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