Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40724-47-8, name is 4-Bromomethylbenzenesulfonamide, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromomethylbenzenesulfonamide
To a stirring solution of 4-(4-(difluoromethoxy)-2-hydroxy-3-methoxyphenyl)-2,3- dihydro-lH-inden-l-one (80 mg, 0.25 mmol) in acetonitrile (10 ml_), was added potassium carbonate (104 mg, 0.75 mmol) and 4-bromomethyl-benzenesulfonamide (125 mg, 0.5 mmol) and the resultant reaction mixture was heated to 80 ¡ãC for 16 h. The reaction mixture was cooled to RT and filtered through celite and the filtrate was concentrated under reduced pressure. The residue was purified by columnchromatography (silica gel, 0-70percent ethyl acetate in pet ether) to afford title compound as a solid (40 mg, 33percent).UPLC-MS (M + l) : 490.11 ; UPLC-MS RT (min) : 2.4
The synthetic route of 40724-47-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LEO PHARMA A/S; NIELSEN, Simon Feldbaek; HORNEMAN, Anne Marie; LAU, Jesper Faergemann; LARSEN, Jens Christian H¡ãjland; WO2011/134468; (2011); A1;,
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