A common heterocyclic compound, 88-96-0, name is Phthalamide, molecular formula is C8H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 88-96-0.
Example 20B (404 mg, 1.13 mmol), triphenylphosphine (455 mg, 1.6 eq.) and phthalamide (222 mg, 1.4 eq.) were mixed in 3.5 mL of toluene. Then, di-tert-butylazodicarboxylate (DBAD, 398 mg, 1.6 eq.) was added. The reaction flask was flushed with argon and then heated to 90 C. After stirring overnight at 90 C., the mixture was cooled to room temperature, concentrated and the resulting oil was purified by column chromatography (eluding with 20% to 40% ethyl acetate in hexane) to give the title compound (684 mg).
The synthetic route of Phthalamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pei, Zhonghua; Geldern, Thomas von; Madar, David J.; Li, Xiaofeng; Basha, Fatima; Yong, Hong; Longenecker, Kenton L.; Backes, Bradley J.; Judd, Andrew S.; Mulhern, Matthew M.; Stewart, Kent D.; US2007/49596; (2007); A1;,
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