These common heterocyclic compound, 7341-96-0, name is Propiolamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 7341-96-0
Aimine (0.24 mmol)Rhodium acetate (0.0024 mmol) and molecular sieves (300 mg) were mixed in 10 mL single-necked vials,Oil pump for nitrogen ventilation, with 1mL syringe by adding 1mL re-steamed CH2Cl2 solution, prepared into a mixed solution A,And the mixture was stirred at room temperature for 10 minutes.The aryl diazonium compound (0.2 mmol) and the amide compound (0.2 mmol) were dissolved in 1 mL of re-evaporated CH2Cl2 To prepare solution B. Solution B was added to the mixed solution A at 25 C with a syringe pump over 1 hour. The mixture is stirred for 3 to 12 hours and the reaction mixture is purified by column chromatography to give pure product as shown in formula (k)For methyl(2S, 3S) -3- (4-bromophenyl) -3 – ((2-hydroxyphenyl) amino) -2- (4-chlorophenyl) -2-propiolamide propionate Rate of 70%Dr value equal to> 95: 5, HPLC purity is 95%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7341-96-0.
Reference:
Patent; East China Normal University; Liu Shunying; Lei Ruirui; Jia Kaili; Wu Yong; Liu Donglan; Dong Suzhen; Hu Wenhao; (42 pag.)CN106831474; (2017); A;,
Amide – Wikipedia,
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