6292-59-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, A new synthetic method of this compound is introduced below.
EXAMPLE 9; Synthesis of 2-[6-(4-tert-Butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl-4-yloxy]-ethanol acetyl ester; In a 3000 ml round-bottom flask under nitrogen atmosphere, 4-tert-butyl-benzenesulfonamide (103 g, 0.480 mol) and potassium carbonate (166 g, 1.200 mol) are suspended in N,N-dimethyl-acetamide (300 ml) and acetonitrile (200 ml) and the mixture is heated at 75-80¡ã C. for about 30 minutes. The reaction mixture is cooled to about 65-70¡ã C. and added with 2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol acetyl ester (200 g, 0.480 mol). The mixture is reacted for 96 hours then diluted with water (1500 ml) and cooled at 0-5¡ã C. for at least 1 hour. The solid is filtered, washing with cold water (4.x.250 ml), and dried at about 45-50¡ã C. for 16-18 hours. 213 g of a solid crude are obtained, in 75percent yield. The resulting product is used for the next reaction, as described in Example 7.
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Reference:
Patent; Dipharma Francis S.r.l.; US2009/156811; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics