57561-39-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57561-39-4, name is tert-Butyl (2-hydroxyethyl)(methyl)carbamate, A new synthetic method of this compound is introduced below.
To a well-stirred solution of N-Boc-N-Me-glycinol (3.5 g, 20 mmol) in DMSO (20 mL) cooled with an ice-water bath was add allyl bromide (3.6 g, 30.0 mmol), followed by finely ground KOH powder (3.5 g, 30.0 mmol) over 15 minutes. The resulting solution was stirred for overnight at room temperature. The resulting mixture was partitioned between 5% aq. HOAc (50mL) and ethyl acetate (200ml). The organic layer was separated, washed with brine, dried with sodium sulfate, filtered, and concentrated, then purified by flash chromatography eluting with 10% to 80% ethyl acetate/hexane. Yield of product 4.1g, 95%. Ion(s) found by LCMS: M+H =216.3.
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Reference:
Patent; CIDARA THERAPEUTICS, INC.; BALKOVEC, James, M.; BENSEN, Daniel, C.; BORCHARDT, Allen; BRADY, Thomas, P.; CHEN, Zhi-Yong; COLE, Jason; DO, Quyen-Quyen, Thuy; DOEHRMANN, Simon; JIANG, Wanlong; LAM, Thanh; NONCOVICH, Alain; TARI, Leslie, W.; (797 pag.)WO2020/51498; (2020); A1;,
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