In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 90-16-4 as follows. 90-16-4
General procedure: Propargyl bromide (1.2 mmol) was added to a solution of 1aa or 1bb or 1cc (1.0 mmol) and K2CO3 (3.0 mmol) in CH3CN (25 mL) under a nitrogen atmosphere. The mixture was stirred at room temperature for 3 h. After completion of the reaction (confirmed by TLC), the mixture was diluted with ice-water (60 mL) and extracted with EtOAc(3¡Á15 mL). The organic layers were collected, combined, dried over anhydrous Na2SO4, filtered and concentrated under low vacuum. The residue was purified by column chromatography using hexane- EtOAc as eluent to afford the title compound.
According to the analysis of related databases, 90-16-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Gautham Shenoy; Misra, Parimal; Pal, Manojit; Bioorganic Chemistry; vol. 91; (2019);,
Amide – Wikipedia,
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