632-24-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 632-24-6, name is 2-(Sulfamoylamino)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: 2-Sulfamoylbenzoic acid or 3-sulfamoylbenzoic acid(0.25 mmol) was placed in a 25-mL round-bottomed flaskand SOCl2 (3 mL) was added dropwise at 0C with stirring.The reaction mixture was placed in an 80C oil bath andrefluxed for 2 h. The reaction mixture was cooled to roomtemperature and the volatiles were removed in vacuum byrotary evaporation, leaving a light-yellow oil. Separately, thesolution of the benzyl-protected L-proline 4a (60 mg, 0.25mmol) and TEA (56 mg, 0.55 mmol) in anhydrous DCM (5mL) was prepared under argon. The solution of the obtainedbenzoyl chloride in anhydrous DCM (5 mL) was added tothe solution of the L-proline at 0 C and the reaction mixturewas stirred at room temperature until completion. The mixturewas diluted with DCM (70 mL) and washed successivelywith sat. NaHCO3 (60 mL) and brine (60 mL). Theorganic layer was dried over Na2SO4, filtered and concentratedunder reduced pressure. The residue was purified byflash column chromatography (PE: EA=2: 1) to afford 6b or7b.
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Reference:
Article; Liu, Xinyu; Dong, Shengjie; Ma, Yuru; Xu, Hu; Zhao, Hongxia; Gao, Qingzhi; Medicinal Chemistry; vol. 15; 2; (2019); p. 196 – 206;,
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