354-38-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 354-38-1 name is 2,2,2-Trifluoroacetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Trifluoroacetamide (4.4 g, 38.9 mmol), magnesium oxide (3.1 g, 77.7 mmol), rhodium(II) acetate dimer (217 mg, 0.49 mmol) and iodobenzene diacetate (9.4 g, 29.1 mmol) were added to a solution of 3-(2,6-difluoro-phenylmethanesulfanyl)-5,5-dimethyl- 4,5-dihydroisoxazole (5 g, 19.4 mmol) in dichloromethane (150 ml) under nitrogen and the grey suspension was stirred for 12 hours at room temperature. The mixture was filtered and the filtrate was concentrated. The crude product was purified by chromatography on silica gel (eluent: hexane / ethyl acetate) to give the product (Compound No.1.09 of Table 65) (6.7 g, 90% purity, 84% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2,2-Trifluoroacetamide, and friends who are interested can also refer to it.
Reference:
Patent; SYNGENTA LIMITED; WO2006/37945; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics