Adding some certain compound to certain chemical reactions, such as: 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121492-06-6. 121492-06-6
To a stirred solution of 135 1-fluoro-4-nitrobenzene (1.0 g, 7.09 mmol, 1.0 eq) and 552 tert-butyl (2-aminoethyl)(methyl)carbamate (1.36 g, 7.79 mmol, 1.1 eq) in 47 DMF (20 mL) was added 64 K2CO3 (1.96 g, 14.18 mmol, 2.0 eq) at rt. The resulting mixture was stirred at 90 C. for 12 h. The progress of reaction was monitored by LCMS. The reaction mixture was poured into ice cold 7 water (100 mL), stirred for 5 min, formation of precipitates was observed, which was filtered and dried under vacuum to afford the desired compound, 553 tert-butyl methyl(2-((4-nitrophenyl)amino)ethyl)carbamate (1.72 g, 82.29%) as a yellow solid. (0586) LCMS: 296.1 [M+1]+
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of N-Boc-(2-Aminoethyl)-N-methylamine.
Reference:
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
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