In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 127-77-5 as follows. 127-77-5
General procedure: To a solution of the amine 3a-l (1 eq) in anhydrous THF (30 mL/mmol) was added4-nitrophenylisocyanate (1 eq). The reaction mixture was stirred at room temperatureovernight, concentrated. Silica cake was prepared in acetone and chromatographicseparation on silica gel (EtOAc/CH2Cl2 = 1/30 to 1/5) gave the expected compound as asolid. Compounds 4e, 4f, 4h and 4l were further recrystallized in acetone to achieve desiredpurity but with substantially lower yields.
According to the analysis of related databases, 127-77-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wang, Xu; Ahn, Yong-Mo; Lentscher, Adam G.; Lister, Julia S.; Brothers, Robert C.; Kneen, Malea M.; Gerratana, Barbara; Boshoff, Helena I.; Dowd, Cynthia S.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 18; (2017); p. 4426 – 4430;,
Amide – Wikipedia,
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