These common heterocyclic compound, 105-60-2, name is epsilon-Caprolactam, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 105-60-2
A. Preparation of 3,3-Dibromoazacycloheptan-2-one To a cold solution of 45.2 g (0.4 mol) of caprolactam in CHCl3 was added 166.0 g (0.8 mol) of PCl5, keeping the temperature less than 5 C. The mixture was brought to room temperature, 2.0 g of ZnCl2 was added, and finally 128 g (0.8 mol) of bromine was added dropwise. After stirring the mixture for 5 hours at room temperature, the solvent and excess bromine was removed by vacuum distillation. The residue was poured into ice water and extracted with CH2 Cl2. The combined organic extracts were washed with sat. Na2 S2 O5, dried over MgSO4, and concentrated in vacuo to give a crude solid. Washing the solid with CH2 Cl2 /toluene yielded the product as a white powder; mp 156-159 C.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 105-60-2.
Reference:
Patent; Nelson Research & Development Co.; US4755535; (1988); A;,
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