The chemical industry reduces the impact on the environment during synthesis 118753-70-1, name is tert-Butyl bis(2-chloroethyl)carbamate, I believe this compound will play a more active role in future production and life. 118753-70-1
To a solution of tert-butyl bis(2-chloroethyl)carbamate (5.08 g) and 2-(3,4-dichlorophenyl)acetonitrile (3.00 g) in anhydrous DMF (50 mL), 60percent (w/w) sodium hydride in oil (1.935 g) was added at 0¡ãC, and the mixture was stirred overnight at 70¡ãC in a nitrogen atmosphere. The reaction mixture was diluted with a saturated aqueous solution of ammonium chloride, followed by extraction with ethyl acetate. The extract was washed with water and saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (ethyl acetate/hexane) to obtain the title compound (3.41 g). MS, found: 254.9.
The chemical industry reduces the impact on the environment during synthesis 118753-70-1. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Takeda Pharmaceutical Company Limited; IMAMURA Keisuke; TOMITA Naoki; ITO Yoshiteru; ONO Koji; MAEZAKI Hironobu; NII Noriyuki; (123 pag.)EP3118200; (2017); A1;,
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