Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 630-22-8, name is 2,2-Dimethylpropanethioamide, A new synthetic method of this compound is introduced below., 630-22-8
at room temperature, to dimethylacetamide (35mL) in a (3- (2- (t-butyl) -5- (2-chloro-pyrimidin-4-yl) thiazol-4-yl) -2-fluorophenyl ) allyl carbamate (3.21g, 9.18mmol, 1.0eq.) was added N- succinimide (1.64g, 9.21mmol, 1.0eq.).When LCMS showed complete disappearance of the starting material, 2,2,2-trimethoxy thio acetamide (1.3g, 11.1mmol, 1.2eq.) And the reaction was heated overnight at 60 deg.] C.LCMS showed the reaction was complete.The reaction was poured into water (250mL), and extracted with ethyl acetate content.Extract was dried over sodium sulfate, filtered, and concentrated under reduced pressure.With 20% ethyl acetate / heptane, silica gel chromatography (300g, 3 “diameter column) to give the crude product, in the form of an oil to provide (3- (2- (t-butyl) -5- (2- chloro-pyrimidin-4-yl) thiazol-4-yl) – 2-fluorophenyl) allyl carbamate (2.92g, 70% yield)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Pulaixike Company; Zhang, Chao; Ibrahim, Prabha N; Nespi, Marika; Shi, Songyuan; Spevak, Wayne; Habets, Gaston G; Burton, Elizabeth A; Hirth, Klaus-Peter; (181 pag.)CN105228983; (2016); A;,
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