New learning discoveries about 3984-14-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,N-Dimethylsulfamide, its application will become more common.

3984-14-3,Some common heterocyclic compound, 3984-14-3, name is N,N-Dimethylsulfamide, molecular formula is C2H8N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 6; N’-(3-chloro-5-oxo-5H-pyridor4′,3′:4,51cycloheptarL2-^lpyridine-7-yl)-N,N-dimethylsulfamide (Compound 7); To a stirred solution of 3,7-dichloro-5H-pyrido[4′ ,3′ :4,5]cyclohepta[l,2-&]pyridin-5-one(80 mg, 0.29 mmol) in dioxane (5 mL) were added Pd2(dba)3 (13 mg, 0.014 mmol), 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (25 mg, 0.043 mmol), N,N-dimethylsulfamide (36 mg, 0.29 mmol), and Cs2CO3 (0.28 g, 0.87 mmol). The reaction mixture was heated to 95 0C for 2 h, cooled to room temperature, treated with water, and extracted with EtOAc. The combined organics were washed with brine, dried (Na2SO4), concentrated, and purified by flash chromatography to afford the title compound. 1H NMR (600 MHz, CDCl3) delta 8.79 (d, IH); 8.86 (d, 1H);8.76 (s, IH); 8.66 (br s, IH); 8.54 (d, IH); 7.96 (s, IH); 7.38 (d, IH); 7.27 (d, IH); 2.99 (s, 6H). LRMS (ESI) calc’d for (C15H13ClN4O3S) [M+H]+, 365.0; found 365.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,N-Dimethylsulfamide, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2007/50401; (2007); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics