The chemical industry reduces the impact on the environment during synthesis 3144-09-0, name is Methylsulfonamide, I believe this compound will play a more active role in future production and life. 3144-09-0
To a 50 mL three-necked flask, add 1.22 g (10.0 mmole) of benzoic acid and 12 mL of chloroform and stir at room temperature for about 5 minutes. Thereafter, the internal temperature was adjusted to around 5 C. by cooling with external cooling in an ice water bath, and then 1.484 g (5.0 mmole) of triphosgene and 3.036 g (30 mmole) of triethylamine were added in turn, (10.0 mmole) of methanesulfonamide was added thereto, and the mixture was stirred for about 5 minutes. Then, the ice water bath was removed and the temperature was raised to room temperature. While stirring for about 1 hour, the reaction was carried out by thin film chromatography (TLC) After confirming the completion of the reaction, the reaction solvent was distilled off under reduced pressure, and 15 mL of water was added to the resulting solid to dissolve the solid salt formed by the neutralization reaction of triethylamine and hydrochloric acid produced as a by-product The desired compound, acylsulfonamide, is dispersed in a solid form and stirred. After filtration, the filtrate was washed with water, and the obtained solid was dried to obtain 1.89 g (yield: 94.9%) of acyl sulfoneamide as a target compound in a solid form.
The chemical industry reduces the impact on the environment during synthesis 3144-09-0. I believe this compound will play a more active role in future production and life.
Reference:
Patent; HANKYONG NATIONAL UNIV. Industry-University Cooperation Foundation; Kim Mi-su; Han Gi-jong; (8 pag.)KR2017/136043; (2017); A;,
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