1943-79-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1943-79-9 name is Phenyl methylcarbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 10 Synthesis of N-methyl-N’-phenyl urea: 15.1 g. of phenyl N-methylcarbamate, 9.3 g. of aniline and 5.4 g. of the tetraethylammonium salt of 2-hydroxy-5-nitro-pyridine are refluxed in 200 ml. of ethanol for 5 hours. The reaction solution is concentrated, and the residue is dissolved in 100 ml. of chloroform, washed successively with 50 ml. of 1N sodium carbonate, 50 ml. of 1N hydrochloric acid and 100 ml. of water, and dried. By concentrating to dryness and recrystallizing from 120 ml. of ethanol, crystals of N-methyl-N-phenylurea having a m.p. of 150 – 151C. are obtained in 91% yield. When phenyl N-methyldithiocarbamate is used in place of phenyl N-methylcarbamate, N-methyl-N’-phenylthiourea is obtained in 79% yield, m.p. 113C. In either case, the reaction rate is considerably lower without the catalyst than with the catalyst.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Kyowa Hakko Kogyo Co., Ltd.; US3963728; (1976); A;,
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