16982-21-1, A common compound: 16982-21-1, name is Ethyl 2-amino-2-thioxoacetate, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
[00144] Synthesis of ethyl 2-amino-2-hydrazonoacetate (6): Ethyl 2-amino-2- thioxoacetate (5) (5g, 37.5 mmol) was dissolved in ethanol and cooled to 0 C. Hydrazine in THF (1M, 37.5 mmol) was added dropwise and stirred at ambient temperature for lh. The reaction mixture was concentrated, white flakes of ethyl 2- amino-2-hydrazonoacetate were obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-amino-2-thioxoacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DODD, Dharmpal, S.; MUSSARI, Christopher, P.; BHIDE, Rajeev, S.; NAIR, Satheesh Kesavan; PAIDI, Venkatram Reddy; KUMAR, Sreekantha Ratna; BANERJEE, Abhisek; SISTLA, Ramesh; PITTS, William, J.; HYNES, John; WO2013/106614; (2013); A1;,
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