New learning discoveries about 1882-71-9

1882-71-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1882-71-9, name is 2-Amino-5-methoxybenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 29: (4-Chloro-phenyl)-{4-[4-hydroxy-l-(6-methoxy-2-trifluoromethyl- quinazolin-4-yl)-pyrrolidin-3-yl]-piperazin-l-yl}-methanone[00236] Step 1 : 6-methoxy -2-trifluoromethyl-3H-quinazolin-4-one[00237] To 2.99 mmoles of 2-amino-5-methoxy anthranilic acid in 1OmL acetonitrile, add 14.9 mmoles of pyridine. The reaction mixture was cooled in ice and then 8.97 mmoles of trifluoroacetic EPO anhydride was added to the reaction mixture and it was slowly warmed to room temperature and allowed to stir for 2 hours. This reaction mixture was added to an ice cooled suspension of 11.96 mmoles ammonium carbonate in 5mL acetonitrile and it was allowed to warm to room temperature and stirred overnight. The reaction mixture was concentrated to a thick oil, 1OmL acetic acid was added to the residue and it was heated at 118-1200C for 2.5-3 hours. The reaction mixture was concentrated and then a 1:1 soln of ethanol-water was added, the white solid obtained was filtered and washed with fresh cold ethanol-water and vaccum dried to yield the title compound in 74 percent yield. LC-MS: m/z= 245 (M+ +1)

The synthetic route of 1882-71-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/71875; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics