53297-68-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53297-68-0, name is 2-Chloro-4-sulfamoylaniline belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The title compound was prepared from 2,5-dichlorophenyl isothiocyanate, according to the procedure described in Example 1, Step 1. MS m/z: 247 (M+H)+. Step 2: {[1-(2,5-dichlorophenyl)-1H-tetrazol-5-yl]thio}acetic acid The title compound was prepared from 1-(2,5-dichlorophenyl)-lH-tetrazole-5-thiol according to the procedure described in Example 1, Step 2. ?H NMR (300 MHz, DMSO-d6) 8: 13.16 (bs, 1H), 8.09 (d, J = 2.2 Hz, 1H), 7.94-7.83 (m, 2H), 4.22 (s, 2H). MS m/z: 305 (M+H)+. Step 3: N-[4-(aminosulfonyl)-2-chlorophenyl] -2-( [ 1 -(2,5 -dichlorophenyl)- lH-tetrazol-5- yl]thio } acetamide. The title compound was prepared from ( [ 1 -(2,5-dichlorophenyl)- lH-tetrazol-5- yl] thio}acetic acid and and 4-amino-3-chlorobenzenesulfonamide according to the procedure described in Example 14, Step 2. lH NMR (300 MHz, DMSO-d6) 8: 10.18 bs, (exchangeable proton, <1H), 8.11 (d, J = 2.0 Hz, 1H), 8.00 (d, J = 8.4 Hz, 1H), 7.95-7.84 (m, 3H), 7.76 (dd, J1 = 8.4 Hz, J2 = 2.0 Hz, 1H), 4.50 (s, 2H). MS m/z: 493 (M+H)+.
The synthetic route of 53297-68-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; WO2005/115147; (2005); A2;,
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