As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4664-01-1 name is 3,4-Pyridinedicarboximide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 4664-01-1
NaOH (10% aqueous, 640 ml) was cooled to 7 C. and bromine (15 ml, 286.82 mmol) added dropwise. Pyrrolo[3,4-c]pyridine-1,3-dione (41.711 g, 281.6 mmol) was then added to the reaction mixture before it was heated to 80 C. for 30 minutes. After this time the reaction was allowed to warm to 37 C. and the pH modified to 5.5 by the addition of acetic acid (70 ml). A suspension formed that was removed by filtration and washed with 20 ml of ice cold methanol to give the title compound (26.58 g, 68.33%) in a suitably clean form to be used without any further purification. m/z (LC-MS, ESP): 139 [M+H]+, R/T=0.72 mins.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,4-Pyridinedicarboximide, and friends who are interested can also refer to it.
Reference:
Patent; Kudos Pharmaceuticals Ltd; US2006/199804; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics