6331-71-1, A common heterocyclic compound, 6331-71-1, name is 4-Amino-N,N-dimethylbenzamide, molecular formula is C9H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3: Synthesis of methyl 5-(N-(4- (dimethylcarbamoyl)phenyl)sulfamoyl)thiophene-2-carboxylate (Intermediate 75) To a solution of 4-amino-N,N-dimethylbenzamide (Int. 74) (57 g, 347 mmol) in pyridine (570 L, 7.06 mmol) kept at 0 degrees in an ice/water bath, methyl 5-(chlorosulfonyl)thiophene-2-carboxylate (100 g, 417 mmol) was added and the mixture stirred at 0 degrees for 3hr. The reaction mixture was diluted with HCl IN and extracted with AcOEt (x2). The organic phase was dried over Na2SO4 and concentrated under vacuum to give 100 mg of 5-(N-(4- (dimethy lc arb amoy l)pheny 1) sulf amoy l)thiophene -2 -carb oxy late (Int . 75).
The synthetic route of 6331-71-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIESI FARMACEUTICI S.p.A.; ARMANI, Elisabetta; CAPALDI, Carmelida; CARZANIGA, Laura; ESPOSITO, Oriana; WO2013/182451; (2013); A1;,
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