As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20348-09-8 name is 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 20348-09-8
Step 1. 7-Bromo-2H-pyrido[3,2-b]1,4-oxazin-3(4H)-one To a solution of 5.6 g 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one dissolved in 85 ml of DMF under nitrogen is added 7.96 g NBS in 50 ml of DMF. This is allowed to stir at room temperature overnight. To this is added 35 ml of water and the mixture is chilled The solid material which separates is filtered and washed with 3*100 ml H2 O. This is then dried under vacuum at 70 C. and then used directly in the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Rorer Pharmaceutical Corporation; US4906629; (1990); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics