711007-44-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 711007-44-2, name is 2,3-Diaminobenzamide, A new synthetic method of this compound is introduced below.
Example 90G 2-((1R,5S)-6-((S)-1-phenylethyl)-6-azabicyclo[3.2.1]octan-5-yl)-1H-benzo[d]imidazole-4-carboxylic acid A mixture of (1R,5S)-6-((S)-1-phenylethyl)-6-azabicyclo[3.2.1]octane-5-carbaldehyde (2.0 g, 8.2 mmol), 2,3-diaminobenzamide (1.85 g, 8.2 mmol) and KHSO3 (2.14 g, 20.6 mmol) in DMA (30 mL) was stirred at 140 C. for 17 h. The reaction mixture was poured into ice. The resulting mixture was extracted with ethyl acetate three times. The combined organic layers were washed brine twice and dried over anhydrous Na2SO4. The solvent was removed and the residue was purified by column (silica gel, Hex/EtOAc/HOAc=2:1:0.01) to yield 2-((1R,5S)-6-((S)-1-phenylethyl)-6-azabicyclo[3.2.1]octan-5-yl)-1H-benzo[d]imidazole-4-carboxylic acid (930 mg, 30%). 1H NMR (DMSO, 400 MHz), delta: 10.9~11.2 (s,1H), 7.72~7.80 (m, 1H), 7.80~7.90 (m, 1H), 7.40~7.58 (m, 2H), 7.19~7.40 (m, 4H), 3.95~4.05 (m, 1H), 3.12~3.23 (m, 1H), 2.22~2.46 (m, 4H), 1.68[1.88 (m, 2H), 1.42~1.59 (m, 2H), 1.15~1.26 (m, 2H), 0.69~0.80 (m, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LEAD THERAPEUTICS, INC.; US2009/62268; (2009); A1;,
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