326-67-0, A common heterocyclic compound, 326-67-0, name is N-(2-Fluoro-4-methylphenyl)acetamide, molecular formula is C9H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Chlorosulfonic acid(20.56 g,176.46 mmol,5 equiv.)was slowly added to N-(2-fluoro-4-methylphenyl)acetamide(5.90 g,35.29 mmol,1 equiv.)keeping the temperature of the reaction mixture below 50 C. The resulting mixture was then heated to 70 C for 4 hours. After cooling to room temperature,the reaction mixture was then poured carefully into ice,the precipitate was filtered,washed well with distilled water and dried to get 7.3 g of crude product as light brown solid. The crude product thus obtained was further used as such without any purification. NMR(CDCI3): delta 9.09(d,J = 7.6 Hz,1H),7.48(bs,1H),7.14(d, J = 10.8 Hz,1H),2.72(s,3H),2.25(s,3H).
The synthetic route of N-(2-Fluoro-4-methylphenyl)acetamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INSECTICIDES (INDIA) LIMITED; OAT AGRIO CO., LTD.; IMAI, Tetsuya; KUMAWAT, Surendra Kumar; SINGH, Manish Kumar; CHAUHAN, Pramod Kumar; BHATT, Ashish; SURAMWAR, Nikhil Vilas; SHELKE, Amol Vasant; SINGH, Rajesh Kumar; KISHORE, Ram; (138 pag.)WO2018/51252; (2018); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics