Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51-06-9, name is 4-Amino-N-(2-diethylaminoethyl)benzamide, A new synthetic method of this compound is introduced below., 51-06-9
To a solution of procainamide (26 mg, 0.112 MMOL) in DICHLOROMETHANE (1.5 mL) under inert atmosphere were triethylamine (31 uL) and 4-trifluoromethoxyphenyl isocyanate (30 , uL, 0.145 MMOL) added. The reaction was stirred for three days. PS-Trisamine (0. 16 g, 3.58 mmol/g, 0.56 MMOL) was added and the reaction was stirrede for two more days. The resin was filtered off and the reaction mixture was concentrated in vacuo. The crude product was purified by acidic ion exchange chromatography (SCX-colon) giving 29 mg (59%) of the title product. LCMS (AN20P10) : RT = 5.52 min, (M-1) = 439.0 m/z.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; 7TM PHARMA A/S; LITTLE, Paul Brian; WO2004/48319; (2004); A1;,
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