Some common heterocyclic compound, 144-80-9, name is N-((4-Aminophenyl)sulfonyl)acetamide, molecular formula is C8H10N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 144-80-9
General procedure: A mixture of appropriate sulfonamide 1 (10 mmol) in DMF (20 mL) and the appropriate isothiocyanate (10 mmol) in dioxin (20 mL) was heated on a water bath for 1 h, cooled and then poured onto ice cooled water. The pale yellow solid thus obtained was filtered and recrystallized from ethanol as needles.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 144-80-9, its application will become more common.
Reference:
Article; Faidallah, Hassan M.; Khan, Khalid A.; Journal of Fluorine Chemistry; vol. 142; (2012); p. 96 – 104;,
Amide – Wikipedia,
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